Hepato‐preferential insulins: I s this the end, or the end of the beginning?
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چکیده
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Hepato‐preferential insulins: Is this the end, or the end of the beginning?
Basal insulin peglispro (BIL) is a novel insulin analogue that binds insulin lispro covalently via a urethane bond to a 20-kDa polyethylene glycol molecule (PEG). This analogue, therefore, has a molecular weight of ~25.8 kDa, approximately three times greater than that of native insulin or most insulin analogues. Its hydrodynamic size, however, appears to be even larger, ~90 kDa, similar to a g...
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ژورنال
عنوان ژورنال: Diabetes, Obesity and Metabolism
سال: 2016
ISSN: 1462-8902,1463-1326
DOI: 10.1111/dom.12756